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   下载文件名   Antibody Levels Poorly Reflect on the Frequency of Memory B Cells Generated following SARS-CoV-2, Seasonal Influenza, or EBV Infection   发布时间 2023-03-18
下载次数
  1  次  
   描述 The scope of immune monitoring is to define the existence, magnitude, and quality of immune mechanisms operational in a host. In clinical trials and praxis, the assessment of humoral immunity is commonly confined to measurements of serum antibody reactivity without accounting for the memory B cell potential. Relying on fundamentally different mechanisms, however, passive immunity conveyed by pre-existing antibodies needs to be distinguished from active B cell memory. Here, we tested whether, in healthy human individuals, the antibody titers to SARS-CoV-2, seasonal influenza, or Epstein–Barr virus antigens correlated with the frequency of recirculating memory B cells reactive with the respective antigens. Weak correlations were found. The data suggest that the assessment of humoral immunity by measurement of antibody levels does not reflect on memory B cell frequencies and thus an individual’s potential to engage in an anamnestic antibody response against the same or an antigenically related virus. Direct monitoring of the antigen-reactive memory B cell compartment is both required and feasible towards that goal
 
   下载文件名   ELISPOT WORKSHOP   发布时间 2015-01-04
下载次数
  210  次  
   描述 Performance of four-color B cell and three-color T cell ELISPOT utilizing optimized, standardized protocols in a LIVE DEMONSTRATION — Detection of Immunoglobulin classes and IgG subclasses in a four-color ImmunoSpot ® Assay — Detection of IFN-γ, Granzyme B, and TNF-α in a three-color ImmunoSpot ® Assay   Automated Live/Dead PBMC Counting using a CTL S6 Ultimate Fluorescent Analyzer — Assessing the quality of stored PBMC   How Flow Cytometry and ELISPOT complement each other in immune diagnostics — Information that ELISPOT can provide but Flow Cytometry cannot   Detecting B cell autoimmunity in Multiple Sclerosis — Diagnosis of the disease and the ability to monitor its activity   Measuring B cell affinity ... And much, much more!
 
   下载文件名   Standard preanalytical coding for biospecimens: Review and implementation of the Sample PREanalytical Code (SPREC)   发布时间 2014-11-19
下载次数
  33  次  
   描述 Standard preanalytical coding for biospecimens: Review and implementation of the Sample PREanalytical Code (SPREC)
 
   下载文件名   How much of a Virus-Specific CD8 T Cell   发布时间 2014-11-19
下载次数
  35  次  
   描述 How much of a Virus-Specific CD8 T Cell Reactivity is Detected with Peptide Pool when Compared to Individual Peptides?
 
   下载文件名   Overview of Serum-Free Media   发布时间 2014-11-19
下载次数
  26  次  
   描述 Overview of Serum-Free Media
 
   下载文件名   PBMC Info Sheet   发布时间 2014-11-19
下载次数
  35  次  
   描述 PBMC Info Sheet
 
   下载文件名   PBMC Poster   发布时间 2014-11-19
下载次数
  23  次  
   描述 PBMC Poster
 
   下载文件名    Optimal Thawing of Cryopreserved PBMC   发布时间 2014-11-19
下载次数
  36  次  
   描述 Optimal Thawing of Cryopreserved PBMC for Use in High-throughput Human Immune Monitoring Studies (Publication)
 
   下载文件名    Resting of Cryopreserved PBMC   发布时间 2014-11-19
下载次数
  23  次  
   描述 Resting of Cryopreserved PBMC Does Not Generally Benefit the Performance of Antigen-Specific T Cell ELISPOT Assays (Publication)
 
   下载文件名   ePBMC®: Cryopreserved PBMC   发布时间 2014-11-19
下载次数
  26  次  
   描述 ePBMC®
 
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